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Hippocampal gray matter volume alterations in patients with first-episode and recurrent major depressive disorder and their associations with gene profiles

15 Feb 2025

Abstract excerpt

BACKGROUND: Recent studies indicate that patients with first-episode drug-naïve (FEDN) and recurrent major depressive disorder (R-MDD) exhibit distinct atrophy patterns in the hippocampal subregions along the proximal-distal axis. However, it remains unclear whether such differences occur along the long axis and how they may relate to specific genes. METHODS: In the present study, we analyzed T1-weighted images...

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PMID: 39955494
DOI: 10.1186/s12888-025-06562-4

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