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The Relationship Between Family History of Depression and Brain Structure and Function: A Systematic Review of Large Cohorts.

Biological psychiatry - 1 Sept 2026

Woodruff James O, Yangchen Tenzin, Kelsall Nora C, Weissman Myrna M, McIntire Laura Beth, Talati Ardesheer, van Dijk Milenna T

Abstract excerpt

Family history (FH) of major depression is a well-replicated risk factor for developing the disorder. Studying individuals who may be at high familial risk but are symptom free may allow us to better distinguish mechanisms predisposing individuals to depression from mechanisms that arise from having the disorder. Neuroimaging studies using such high-risk designs have suggested several cortical and subcortical...

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Identifiers

PMID: 41547389
DOI: 10.1016/j.biopsych.2026.01.006
PMCID: PMC13254834

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FH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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