Different effect of adverse childhood experiences on white matter microstructure in major depression and bipolar disorder: moderating role of genetic liability.

doi:10.1016/j.euroneuro.2025.11.011

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Article

Different effect of adverse childhood experiences on white matter microstructure in major depression and bipolar disorder: moderating role of genetic liability.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Feb 2026

Paolini Marco, Raffaelli Laura, Bettonagli Valentina, Lorenzi Cristina, Spadini Sara, Bravi Beatrice, Fortaner-Uyà Lidia, Gulino Giulia, Fabbri Chiara, Serretti Alessandro, Zanardi Raffaella, Colombo Cristina, Benedetti Francesco, Poletti Sara

Abstract excerpt

Adverse childhood experiences (ACEs) are risk factors for both major depressive (MDD) and bipolar disorder. ACEs have been associated with white matter (WM) alterations, but whether they have different effects in MDD and BD remains unclear. Polygenic risk scores (PRS) allow for an individual estimation of genetic liabilities for most psychiatric conditions. The aim of the present study was to characterize the...

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PMID: 41389473
DOI: 10.1016/j.euroneuro.2025.11.011

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