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Article

The Multifunctional Role of mTOR in Innate Immunity: Implications for Transplant Immunity

25 Sept 2009

Abstract excerpt

The mammalian target of rapamycin (mTOR) is an evolutionary conserved serine-threonine kinase that senses various environmental stimuli in most cells primarily to control cell growth. Restriction of cellular proliferation by mTOR inhibition led to the use of mTOR inhibitors as immunosuppressants in allogeneic transplantation as well as novel anticancer agents. However, distinct inflammatory side effects such as...

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PMID: 19788500
DOI: 10.1111/j.1600-6143.2009.02832.x

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