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Assessment of CFH and HTRA1 polymorphisms in age-related macular degeneration using classic and machine-learning approaches.

Ophthalmic genetics - 1 Dec 2020

Martínez-Velasco Antonieta, Perez-Ortiz Andric C, Antonio-Aguirre Bani, Martínez-Villaseñor Lourdes, Lira-Romero Esmeralda, Palacio-Pastrana Claudia, Zenteno Juan Carlos, Ramirez Israel, Zepeda-Palacio Claudia, Mendoza-Velásquez Cristina, Camacho-Ordóñez Azyadeh, Ortiz Bibriesca Daniela Michelle, Estrada-Mena F Javier

Abstract excerpt

BACKGROUND: CFH and HTRA1 are pivotal genes driving increased risk for age-related macular degeneration (AMD) among several populations. Here, we performed a hospital-based case-control study to evaluate the effects of three single nucleotide polymorphisms (SNPs) among Hispanics from Mexico. MATERIALS AND METHODS: 122 cases and 249 controls were genotyped using Taqman probes. Experienced ophthalmologists...

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Identifiers

PMID: 32838591
DOI: 10.1080/13816810.2020.1804945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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