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Article

The contribution of genetic factors to phenotype and progression of drusen in early age-related macular degeneration.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie - 1 Aug 2014

Dietzel Martha, Pauleikhoff Daniel, Arning Astrid, Heimes Britta, Lommatzsch Albrecht, Stoll Monika, Hense Hans-Werner

Abstract excerpt

PURPOSE: Genetic factors contribute to the development and progression of age-related macular degeneration (AMD). We aimed to assess the association of drusen as phenotypic characteristics of early AMD and their progression with polymorphisms in the CFH, ABCA1, and ARMS2 genes. METHODS: In the Münster Aging and Retina Study (MARS), drusen were detected in 406 patients with early AMD and 170 healthy controls...

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PMID: 24970616
DOI: 10.1007/s00417-014-2690-7

Genes

CFH
ARMS2
ABCA1

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