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Article

HTRA1 variant confers similar risks to geographic atrophy and neovascular age-related macular degeneration.

Cell cycle (Georgetown, Tex.) - 2 May 2007

Cameron D Joshua, Yang Zhenglin, Gibbs Daniel, Chen Haoyu, Kaminoh Yuuki, Jorgensen Adam, Zeng Jiexi, Luo Ling, Brinton Eric, Brinton Gregory, Brand John M, Bernstein Paul S, Zabriskie Norman A, Tang Shibo, Constantine Ryan, Tong Zongzhong, Zhang Kang

Abstract excerpt

Age-related macular degeneration (AMD) is the most common cause of irreversible visual impairment in the developed world. The two forms of advanced AMD, geographic atrophy (GA) and choroidal neovascularization (wet AMD), represent two types of degenerative processes in the macula that lead to loss of central vision. Soft confluent drusen, characterized by deposits in macula without visual loss are considered a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17426452
DOI: 10.4161/cc.6.9.4157

Genes

HTRA1
CFH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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