Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

C-reactive protein and CFH, ARMS2/HTRA1 gene variants are independently associated with risk of macular degeneration.

Ophthalmology - 1 Aug 2010

Seddon Johanna M, Gensler Gary, Rosner Bernard

Abstract excerpt

PURPOSE: Genetic variants CFH and ARMS2/HTRA1 gene regions as well as high-sensitivity C-reactive protein (CRP) levels are related to age-related macular degeneration (AMD). We evaluated their independent and combined effects on risk of AMD, as well as their interactions. DESIGN: Case-control study. PARTICIPANTS: Subjects with AMD (n = 244) or no or minimal maculopathy (n = 209) in the Age Related Eye Disease...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to C-Reactive Protein
Share to Complement Factor H
Share to Geographic Atrophy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Temperature Requirement A Serine Peptidase 1

Share to Macular Degeneration

Share to Retinal Drusen

Share to Serine Endopeptidases

Share to Surveys and Questionnaires

Source

Open in PubMed Open full text

Identifiers

PMID: 20346514
DOI: 10.1016/j.ophtha.2009.11.020
PMCID: PMC3711558

Genes

CRP
ARMS2
CFH
HTRA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

C-reactive protein and CFH, ARMS2/HTRA1 gene variants are independently associated with risk of macular degeneration.PMID 20346514Read ↗

Polymorphisms in ARMS2/HTRA1 and complement genes and age-related macular degeneration in India: findings from the INDEYE study.Semantic proximity Read ↗

Impact of age-related maculopathy susceptibility 2, high-temperature requirement A serine peptidase 1, and complement factor H genetic variants on clinical phenotypes of age-related macular degeneration.Semantic proximity Read ↗

Association of single nucleotide polymorphisms in CFH, ARMS2 and HTRA1 genes with risk of age-related macular degeneration in Egyptian patients.Semantic proximity Read ↗

CFH (rs1410996), HTRA1 (rs112000638) and ARMS2 (rs10490923) gene polymorphisms are associated with AMD risk in Spanish patients.Semantic proximity Read ↗

Comprehensive analysis of complement factor H and LOC387715/ARMS2/HTRA1 variants with respect to phenotype in advanced age-related macular degeneration.Semantic proximity Read ↗

Elevated C-reactive protein levels and ARMS2/HTRA1 gene variants in subjects without age-related macular degeneration.Semantic proximity Read ↗

Influence of CFH, HTRA1 and ARMS2 haplotype polymorphisms in the development of age-related macular disease.Semantic proximity Read ↗

Gene polymorphisms associated with an increased risk of exudative age-related macular degeneration in a Spanish population.Semantic proximity Read ↗

Variations in five genes and the severity of age-related macular degeneration: results from the Muenster aging and retina study.Semantic proximity Read ↗

Genetic factors associated with age-related macular degeneration: identification of a novel PRPH2 single nucleotide polymorphism associated with increased risk of the disease.Semantic proximity Read ↗

Assessing susceptibility to age-related macular degeneration with genetic markers and environmental factors.Semantic proximity Read ↗

Association analysis of CFH and ARMS2 gene polymorphisms in a Brazilian cohort with age-related macular degeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.