Article
Using genetic variation and environmental risk factor data to identify individuals at high risk for age-related macular degeneration.
PloS one - 24 Mar 2011
Spencer Kylee L, Olson Lana M, Schnetz-Boutaud Nathalie, Gallins Paul, Agarwal Anita, Iannaccone Alessandro, Kritchevsky Stephen B, Garcia Melissa, Nalls Michael A, Newman Anne B, Scott William K, Pericak-Vance Margaret A, Haines Jonathan L
Abstract excerpt
A major goal of personalized medicine is to pre-symptomatically identify individuals at high risk for disease using knowledge of each individual's particular genetic profile and constellation of environmental risk factors. With the identification of several well-replicated risk factors for age-related macular degeneration (AMD), the leading cause of legal blindness in older adults, this previously unreachable...
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