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Article

Histone H3.3K27M Mobilizes Multiple Cancer/Testis (CT) Antigens in Pediatric Glioma.

Molecular cancer research : MCR - 1 Apr 2018

Deng Houliang, Zeng Jianming, Zhang Ting, Gong Longcai, Zhang Hongjie, Cheung Edwin, Jones Chris, Li Gang

Abstract excerpt

Lysine to methionine mutations at position 27 (K27M) in the histone H3 (H3.3 and H3.1) are highly prevalent in pediatric high-grade gliomas (HGG) that arise in the midline of the central nervous system. H3K27M perturbs the activity of polycomb repressor complex 2 and correlates with DNA hypomethylation; however, the pathways whereby H3K27M drives the development of pediatric HGG remain poorly understood. To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29453317
DOI: 10.1158/1541-7786.MCR-17-0460

Genes

ADAM23
ADAMTS1
SPANXA1
SPANXB1
VCY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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