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Article

Therapeutic Targeting of Histone Modifications in Adult and Pediatric High-Grade Glioma

28 Mar 2017

Abstract excerpt

Recent exciting work partly through The Cancer Genome Atlas has implicated epigenetic mechanisms including histone modifications in the development of both pediatric and adult high-grade glioma (HGG). Histone lysine methylation has emerged as an important player in regulating gene expression and chromatin function. Lysine (K) 27 (K27) is a critical residue in all seven histone 3 variants and the subject of...

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Share to Epigenetics and DNA Methylation
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PMID: 28401060
DOI: 10.3389/fonc.2017.00045

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