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Article

The role of COMT polymorphism in modulation of prefrontal activity during verbal fluency in bipolar disorder.

Neuroscience letters - 1 Nov 2020

Devrimci-Ozguven Halise, Hosgoren Alıcı Y, Demirbugen Oz M, Suzen H S, Kale H E, Baskak B

Abstract excerpt

OBJECTIVE: Verbal fluency (VF) impairment is a strong predictor of social functioning in bipolar disorder (BPD). The enzyme catechol-O- methyltransferase (COMT) has a critical role in cognitive responses by modulating dopaminergic activity in the prefrontal cortex (PFC). Here, we investigated the role of COMT polymorphism (i) in VF performance as well as (ii) in modulation of PFC activity during a VF-task in...

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Source

Identifiers

PMID: 32822765
DOI: 10.1016/j.neulet.2020.135310

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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