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Article

COMT val158met polymorphism and molecular alterations in the human dorsolateral prefrontal cortex: Differences in controls and in schizophrenia.

Schizophrenia research - 1 May 2016

Shukla Abhay A, Jha Manish, Birchfield Thomas, Mukherjee Shibani, Gleason Kelly, Abdisalaam Salim, Asaithamby Aroumougame, Adams-Huet Beverley, Tamminga Carol A, Ghose Subroto

Abstract excerpt

The single nucleotide val158met polymorphism in catechol o-methyltransferase (COMT) influences prefrontal cortex function. Working memory, dependent on the dorsolateral prefrontal cortex (DLPFC), has been repeatedly shown to be influenced by this COMT polymorphism. The high activity COMT val isoform is associated with lower synaptic dopamine levels. Altered synaptic dopamine levels are expected to lead to...

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Identifiers

PMID: 27021555
DOI: 10.1016/j.schres.2016.03.019
PMCID: PMC4836991

Genes

COMT
DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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COMT val158met polymorphism and molecular alterations in the human dorsolateral prefrontal cortex: Differences in controls and in schizophrenia.PMID 27021555Read ↗

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