Article

Targeting Immune Signaling Pathways in Graft-Versus-Host Disease; A Signaling-Centric Review of Future Therapeutic Strategies

2025-12-19

Abstract excerpt

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) and next-generation al-logeneic T cell therapies are curative options for hematologic malignancies, but their effi-cacy is often limited by graft-versus-host disease (GvHD), a complex syndrome resulting from dysregulated donor–host immune interactions. GvHD is mediated by interconnected signaling pathways that regulate T cell activation, metabolic and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 390401f6-8e91-5915-ba0b-b72ab1fe35e5
DOI: 10.20944/preprints202512.1707.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting Immune Signaling Pathways in Graft-Versus-Host Disease; A Signaling-Centric Review of Future Therapeutic StrategiesDOI 10.20944/preprints202512.1707.v1Read

New molecules in the therapy of chronic graft-versus-host diseaseSemantic proximity Read

Role of ROCK2 inhibitors in the treatment of chronic graft-versus-host diseaseSemantic proximity Read

Cellular and molecular profiling of T-cell subsets at the onset of human acute GVHDSemantic proximity Read

Advances in understanding the pathogenesis of graft‐versus‐host diseaseSemantic proximity Read

Spatiotemporal Single-Cell Analysis Reveals T Cell Clonal Dynamics and Phenotypic Plasticity in Human Graft-versus-Host DiseaseSemantic proximity Read

Insights into the role of the JAK/STAT signaling pathway in graft- versus -host diseaseSemantic proximity Read

Concise Review: Acute Graft-Versus-Host Disease: Immunobiology, Prevention, and TreatmentSemantic proximity Read

Tissue-infiltrating alloreactive T cells require Id3 to deflect PD-1–mediated immune suppression during GVHDSemantic proximity Read

The JAK/STAT conundrum with mutational heterogeneity, immune defects, and the emergence of targeted therapies.Semantic proximity Read

Improved outcome of HSCT in STAT1 gain-of-function disease following JAK inhibition bridgingSemantic proximity Read

Coordinated Immune Cell Networks in the Bone Marrow Microenvironment Define the Graft versus Leukemia Response with Adoptive Cellular TherapySemantic proximity Read

Myeloid reprogramming by JAK inhibition enhances checkpoint blockade therapySemantic proximity Read