Article
High-resolution phenotyping of early acute rejection reveals a conserved alloimmune signature.
Cell reports - 2 Mar 2021
Harden James T, Wang Xi, Toh Jiaying, Sang Adam X, Brown Ryanne A, Esquivel Carlos O, Martinez Olivia M, Krams Sheri M
Abstract excerpt
Alloimmune responses in acute rejection are complex, involving multiple interacting cell types and pathways. Deep profiling of these cell types has been limited by technology that lacks the capacity to resolve this high dimensionality. Single-cell mass cytometry is used to characterize the alloimmune response in early acute rejection, measuring 37 parameters simultaneously, across multiple time points in two...
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