The 10q26 Risk Haplotype of Age-Related Macular Degeneration Aggravates Subretinal Inflammation by Impairing Monocyte Elimination.

doi:10.1016/j.immuni.2020.07.021

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Article

The 10q26 Risk Haplotype of Age-Related Macular Degeneration Aggravates Subretinal Inflammation by Impairing Monocyte Elimination.

Immunity - 18 Aug 2020

Beguier Fanny, Housset Michael, Roubeix Christophe, Augustin Sebastien, Zagar Yvrick, Nous Caroline, Mathis Thibaud, Eandi Chiara, Benchaboune Mustapha, Drame-Maigné Adèle, Carpentier Wassila, Chardonnet Solenne, Touhami Sara, Blot Guillaume, Conart Jean Baptiste, Charles-Messance Hugo, Potey Anaïs, Girmens Jean-François, Paques Michel, Blond Fréderic, Leveillard Thierry, Koertvely Elod, Roger Jerome E, Sahel José-Alain, Sapieha Przemyslaw, Delarasse Cécile, Guillonneau Xavier, Sennlaub Florian

Abstract excerpt

A minor haplotype of the 10q26 locus conveys the strongest genetic risk for age-related macular degeneration (AMD). Here, we examined the mechanisms underlying this susceptibility. We found that monocytes from homozygous carriers of the 10q26 AMD-risk haplotype expressed high amounts of the serine peptidase HTRA1, and HTRA1 located to mononuclear phagocytes (MPs) in eyes of non-carriers with AMD. HTRA1 induced...

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PMID: 32814029
DOI: 10.1016/j.immuni.2020.07.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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