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Article

Exploring the contribution of ARMS2 and HTRA1 genetic risk factors in age-related macular degeneration.

Progress in retinal and eye research - 1 Nov 2023

Pan Yang, Fu Yingbin, Baird Paul N, Guymer Robyn H, Das Taraprasad, Iwata Takeshi

Abstract excerpt

Age-related macular degeneration (AMD) is the leading cause of severe irreversible central vision loss in individuals over 65 years old. Genome-wide association studies (GWASs) have shown that the region at chromosome 10q26, where the age-related maculopathy susceptibility (ARMS2/LOC387715) and HtrA serine peptidase 1 (HTRA1) genes are located, represents one of the strongest associated loci for AMD. However, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 36581531
DOI: 10.1016/j.preteyeres.2022.101159

Genes

HTRA1
ARMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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