Article
Mast cell infiltration of the choroid and protease release are early events in age-related macular degeneration associated with genetic risk at both chromosomes 1q32 and 10q26.
Proceedings of the National Academy of Sciences of the United States of America - 17 May 2022
Mcharg Selina, Booth Laura, Perveen Rahat, Riba Garcia Isabel, Brace Nicole, Bayatti Nadhim, Sergouniotis Panagiotis I, Phillips Alexander M, Day Anthony J, Black Graeme C M, Clark Simon J, Dowsey Andrew W, Unwin Richard D, Bishop Paul N
Abstract excerpt
Age-related macular degeneration (AMD) is a leading cause of visual loss. It has a strong genetic basis, and common haplotypes on chromosome (Chr) 1 (CFH Y402H variant) and on Chr10 (near HTRA1/ARMS2) contribute the most risk. Little is known about the early molecular and cellular processes in AMD, and we hypothesized that analyzing submacular tissue from older donors with genetic risk but without clinical...
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