Article
Liuwei Dihuang, a traditional Chinese medicinal formula, inhibits proliferation and migration of vascular smooth muscle cells via modulation of estrogen receptors.
International journal of molecular medicine - 1 Jul 2018
Zhang Yayun, Qian Xing, Sun Xin, Lin Chao, Jing Yi, Yao Yuan, Ma Zhi, Kuai Meiyu, Lu Ying, Kong Xueyun, Chen Qi, Wu Xiang, Zhao Xuan, Li Yu, Bian Huimin
Abstract excerpt
The phenotypic modulation of vascular smooth muscle cells (VSMCs) serves an important role in atherosclerosis‑induced vascular alterations, including vascular remodeling. However, the precise mechanisms underlying VSMC phenotypic modulation remain to be elucidated. Our previous study demonstrated that Liuwei Dihuang formula (LWDHF) could improve menopausal atherosclerosis by upregulating the expression of...
Topics
- Actins
- Angiotensin II
- Animals
- Cell Cycle Checkpoints
- Cell Movement
- Cell Proliferation
- Drugs, Chinese Herbal
- Gene Knockdown Techniques
- Humans
- Male