Article
LacZ transgenic mouse models: their application in genetic toxicology.
Mutation research - 1 Jun 1994
Gossen J A, de Leeuw W J, Vijg J
Abstract excerpt
Gene mutations have been implicated in the etiology of cancer, developmental anomalies, genetic disease and aging. Many different methods for mutation detection have been developed and applied to obtain a more fundamental insight in the chain of molecular events that ultimately lead to mutations. Most of these methods, however, can only be applied to cultured cells and therefore do not allow comparative analysis...
Topics
- Animals
- Bacteriophage lambda
- DNA Transposable Elements
- Escherichia coli
- Genetic Vectors
- Lac Operon
- Mice
- Mice, Transgenic
- Models, Genetic
- Mutagenesis, Site-Directed
- Mutagenicity Tests