Article
The mutational signature profile of known and suspected human carcinogens in mice.
Nature genetics - 1 Nov 2020
Riva Laura, Pandiri Arun R, Li Yun Rose, Droop Alastair, Hewinson James, Quail Michael A, Iyer Vivek, Shepherd Rebecca, Herbert Ronald A, Campbell Peter J, Sills Robert C, Alexandrov Ludmil B, Balmain Allan, Adams David J
Abstract excerpt
Epidemiological studies have identified many environmental agents that appear to significantly increase cancer risk in human populations. By analyzing tumor genomes from mice chronically exposed to 1 of 20 known or suspected human carcinogens, we reveal that most agents do not generate distinct mutational signatures or increase mutation burden, with most mutations, including driver mutations, resulting from...
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