Article
A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis.
The Journal of allergy and clinical immunology - 1 Nov 2018
Panganiban Ronald A, Sun Maoyun, Dahlin Amber, Park Hae-Ryung, Kan Mengyuan, Himes Blanca E, Mitchel Jennifer A, Iribarren Carlos, Jorgenson Eric, Randell Scott H, Israel Elliot, Tantisira Kelan, Shore Stephanie, Park Jin-Ah, Weiss Scott T, Wu Ann Chen, Lu Quan
Abstract excerpt
BACKGROUND: Genetic variants in the chromosomal region 17q21 are consistently associated with asthma. However, mechanistic studies have not yet linked any of the associated variants to a function that could influence asthma, and as a result, the identity of the asthma gene(s) remains elusive. OBJECTIVES: We sought to identify and characterize functional variants in the 17q21 locus. METHODS: We used the Exome...
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