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Article

Integrated genomics analysis highlights important SNPs and genes implicated in moderate-to-severe asthma based on GWAS and eQTL datasets.

BMC pulmonary medicine - 16 Oct 2020

Dong Zhouzhou, Ma Yunlong, Zhou Hua, Shi Linhui, Ye Gongjie, Yang Lei, Liu Panpan, Zhou Li

Abstract excerpt

BACKGROUND: Severe asthma is a chronic disease contributing to disproportionate disease morbidity and mortality. From the year of 2007, many genome-wide association studies (GWAS) have documented a large number of asthma-associated genetic variants and related genes. Nevertheless, the molecular mechanism of these identified variants involved in asthma or severe asthma risk remains largely unknown. METHODS: In the...

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PMID: 33066754
DOI: 10.1186/s12890-020-01303-7
PMCID: PMC7568423

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