Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Asthma Risk Gene, GSDMB, Promotes Mitochondrial DNA-induced ISGs Expression

1 Jan 2024

Abstract excerpt

Released mitochondrial DNA (mtDNA) in cells activates cGAS-STING pathway, which induces expression of interferon-stimulated genes (ISGs) and thereby promotes inflammation, as frequently seen in asthmatic airways. However, whether the genetic determinant, Gasdermin B (GSDMB), the most replicated asthma risk gene, regulates this pathway remains unknown. We set out to determine whether and how GSDMB regulates...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Inflammasome and immune disorders
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38737375
DOI: 10.35534/jrbtm.2024.10005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Asthma Risk Gene, GSDMB, Promotes Mitochondrial DNA-induced ISGs ExpressionPMID 38737375Read ↗

Gasdermin B, an asthma-susceptibility gene, promotes MAVS-TBK1 signalling and airway inflammation.Semantic proximity Read ↗

Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways.Semantic proximity Read ↗

From gene identifications to therapeutic targets for asthma: Focus on great potentials of TSLP, ORMDL3, and GSDMBSemantic proximity Read ↗

Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR.Semantic proximity Read ↗

New Insights Relating Gasdermin B to the Onset of Childhood Asthma.Semantic proximity Read ↗

A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis.Semantic proximity Read ↗

STING-ΔN, a novel splice isoform of STING, modulates innate immunity and autophagy in response to DNA virus infectionSemantic proximity Read ↗

GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation.Semantic proximity Read ↗

Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein.Semantic proximity Read ↗

IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in AsthmaSemantic proximity Read ↗

8-Oxoguanine DNA glycosylase-1-driven DNA base excision repairSemantic proximity Read ↗

The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.