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Article

IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma

24 Oct 2017

Abstract excerpt

Abstract Rationale Quantification of type 2 inflammation provided a molecular basis for heterogeneity in asthma. Non–type 2 pathways that contribute to asthma pathogenesis are not well understood. Objectives To identify dysregulated pathways beyond type 2 inflammation. Methods We applied RNA sequencing to airway epithelial brushings obtained from subjects with stable mild asthma not on corticosteroids (n = 19)...

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PMID: 29064281
DOI: 10.1164/rccm.201706-1070oc

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