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Article

MitoQ attenuates brain damage by polarizing microglia towards the M2 phenotype through inhibition of the NLRP3 inflammasome after ICH.

Pharmacological research - 1 Nov 2020

Chen Weixiang, Guo Chao, Huang Suna, Jia Zhengcai, Wang Jie, Zhong Jun, Ge Hongfei, Yuan Jichao, Chen Tunan, Liu Xin, Hu Rong, Yin Yi, Feng Hua

Abstract excerpt

Microglial phenotype plays an important role in secondary injury after intracerebral haemorrhage (ICH), with M1 microglia promoting inflammatory injury and M2 microglia inhibiting neuroinflammation and promoting haematoma absorption. However, there is no effective intervention for regulating the phenotypic transformation of microglia after ICH. This study aimed to elucidate the protective effect of MitoQ, a...

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Identifiers

PMID: 32791262
DOI: 10.1016/j.phrs.2020.105122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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