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Article

Selective modulation of microglia polarization to M2 phenotype for stroke treatment.

International immunopharmacology - 1 Apr 2015

Xia Cong-Yuan, Zhang Shuai, Gao Yan, Wang Zhen-Zhen, Chen Nai-Hong

Abstract excerpt

Resident microglia are the major immune cells in the brain, acting as the first defense of the central nervous system. Following cerebral ischemia, microglia respond to this injury at first and transform from surveying microglia to active state. The activated microglia play a dual role in the ischemic injury, due to distinct microglia phenotypes, including deleterious M1 and neuroprotective M2. However, microglia...

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Identifiers

PMID: 25704852
DOI: 10.1016/j.intimp.2015.02.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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