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Article

Oxymatrine inhibits neuroinflammation byRegulating M1/M2 polarization in N9 microglia through the TLR4/NF-κB pathway.

International immunopharmacology - 1 Nov 2021

Wang Xiao-Long, Chen Fei, Shi Hui, Zhang Man, Yan Lin, Pei Xiu-Ying, Peng Xiao-Dong

Abstract excerpt

Microglia are the primary immune cells involved in the immune response, inflammation, and injury repair in the central nervous system. Under different stimuli, the dual polarization of classically-activated M1 microglia and anti-inflammatory selectively-activated M2 microglia is observed. Oxymatrine (OMT) exerts various anti-inflammatory and neuroprotective effects, but the mechanism underlying its action remains...

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PMID: 34517275
DOI: 10.1016/j.intimp.2021.108139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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