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Rhein Alleviates Cerebral Ischemia/Reperfusion Injury by Inhibiting the Microglial NLRP3 Inflammasome/Pyroptosis Axis and Regulating Microglial M1/M2 Phenotypes.

The American journal of Chinese medicine - 1 Jan 2026

Li Xun, Li Yan, Jing Wei-Peng, Yao Ming-He, Li Ling-Ling, Zhang Hai-Bo, Liu Yan-Jie, Xu Hua-Ming, Ren Dong-Fang, Ma Hui-Fen, Yuan Pei-Pei, Li Ya-Min, Fu Jun-Min, Wang Hui, Fang Xiao-Yan, Miao Ming-San

Abstract excerpt

The activation of the NLRP3 inflammasome is critical to inducing microglial activation and pyroptosis following cerebral ischemia/reperfusion (I/R). Suppressing the neurotoxicity of activated microglia has become an effective approach for treating cerebral I/R injury. Rhein is an anthraquinone compound found in rheum, and possesses anti-inflammatory, antagonistic, and antifibrotic effects. This study assessed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41684092
DOI: 10.1142/S0192415X26500096

Genes

NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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