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The Novel Nrf2 Activator Omaveloxolone Regulates Microglia Phenotype and Ameliorates Secondary Brain Injury after Intracerebral Hemorrhage in Mice.

Oxidative medicine and cellular longevity - 1 Jan 2022

Hu Libin, Cao Yang, Chen Huaijun, Xu Lei, Yang Qiguo, Zhou Hang, Li Jianru, Yu Qian, Dou Zhangqi, Li Yin, Yan Feng, Liu Fuyi, Chen Gao

Abstract excerpt

The polarization of microglia is recognized as a crucial factor in reducing neuroinflammation and promoting hematoma clearance after intracerebral hemorrhage (ICH). Previous studies have revealed that redox components participate in the regulation of microglial polarization. Recently, the novel Nrf2 activator omaveloxolone (Omav) has been validated to improve neurological function in patients with...

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Identifiers

PMID: 35308167
DOI: 10.1155/2022/4564471
PMCID: PMC8933082

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