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Article

Protocatechuic Acid Suppresses Microglia Activation and Facilitates M1 to M2 Phenotype Switching in Intracerebral Hemorrhage Mice.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Jun 2021

Xi Zhiyu, Xu Canxin, Chen Xiao, Wang Baofeng, Zhong Zhihong, Sun Qingfang, Sun Yuhao, Bian Liuguan

Abstract excerpt

OBJECTIVES: Microglia activation, a key process in secondary injury following intracerebral hemorrhage (ICH), is divided to M1 and M2 phenotype. Protocatechuic acid (PCA) is a phenolic acid been proved neuroprotection in ICH without understanding of details. Thus, this study aimed to observe the influence of PCA on microglia activation and explore underlying mechanisms. MATERIALS AND METHODS: To assess PCA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33813082
DOI: 10.1016/j.jstrokecerebrovasdis.2021.105765

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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