Article
NLRP3 inflammasome inhibitor ameliorates ischemic stroke by reprogramming the phenotype of microglia/macrophage in a murine model of distal middle cerebral artery occlusion.
Neuropathology : official journal of the Japanese Society of Neuropathology - 1 Jun 2022
Jia Hongning, Qi Xiaoyuan, Fu Lan, Wu Huijun, Shang Jinxing, Qu Mingwei, Yang Chaoping, Wang Jianping
Abstract excerpt
Stroke is one of the leading causes of death and disability worldwide. NLRP3 inflammasome has an essential role in the neuropathology of stroke. Recent studies report that shifting the microglial M1 phenotype to the M2 phenotype protects against ischemic stroke. In the present study, the precise effects of Tranilast, a NLPR3 inflammasome inhibitor, on stroke were evaluated. We established a murine model of distal...
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