Article
GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer.
Nature communications - 7 Aug 2020
Zhou Wei, Brumpton Ben, Kabil Omer, Gudmundsson Julius, Thorleifsson Gudmar, Weinstock Josh, Zawistowski Matthew, Nielsen Jonas B, Chaker Layal, Medici Marco, Teumer Alexander, Naitza Silvia, Sanna Serena, Schultheiss Ulla T, Cappola Anne, Karjalainen Juha, Kurki Mitja, Oneka Morgan, Taylor Peter, Fritsche Lars G, Graham Sarah E, Wolford Brooke N, Overton William, Rasheed Humaira, Haug Eirin B, Gabrielsen Maiken E, Skogholt Anne Heidi, Surakka Ida, Davey Smith George, Pandit Anita, Roychowdhury Tanmoy, Hornsby Whitney E, Jonasson Jon G, Senter Leigha, Liyanarachchi Sandya, Ringel Matthew D, Xu Li, Kiemeney Lambertus A, He Huiling, Netea-Maier Romana T, Mayordomo Jose I, Plantinga Theo S, Hrafnkelsson Jon, Hjartarson Hannes, Sturgis Erich M, Palotie Aarno, Daly Mark, Citterio Cintia E, Arvan Peter, Brummett Chad M, Boehnke Michael, de la Chapelle Albert, Stefansson Kari, Hveem Kristian, Willer Cristen J, Åsvold Bjørn Olav
Abstract excerpt
Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. To better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis at 22.4 million genetic markers in up to 119,715 individuals and identify 74 genome-wide significant loci for TSH, of which 28 are previously unreported. Functional experiments show that the thyroglobulin protein-altering variants P118L...
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