Article
The Effects of Common Genetic Variation in 96 Genes Involved in Thyroid Hormone Regulation on TSH and FT4 Concentrations.
The Journal of clinical endocrinology and metabolism - 17 May 2022
Sterenborg Rosalie B T M, Galesloot Tessel E, Teumer Alexander, Netea-Maier Romana T, Speed Doug, Meima Marcel E, Visser W Edward, Smit Johannes W A, Peeters Robin P, Medici Marco
Abstract excerpt
OBJECTIVE: While most of the variation in thyroid function is determined by genetic factors, single nucleotide polymorphisms (SNPs) identified via genome-wide association analyses have only explained ~5% to 9% of this variance so far. Most SNPs were in or nearby genes with no known role in thyroid hormone (TH) regulation. Therefore, we performed a large-scale candidate gene study investigating the effect of...
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