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Transcriptome-wide association study identifies multiple genes and pathways associated with thyroid function.

Human molecular genetics - 4 Jun 2022

Ke Xin, Tian Xin, Yao Shi, Wu Hao, Duan Yuan-Yuan, Wang Nai-Ning, Shi Wei, Yang Tie-Lin, Dong Shan-Shan, Huang Dageng, Guo Yan

Abstract excerpt

Thyroid dysfunction is a common endocrine disease measured by thyroid-stimulating hormone (TSH) level. Although >70 genetic loci associated with TSH have been reported through genome-wide association studies (GWASs), the variants can only explain a small fraction of the thyroid function heritability. To identify novel candidate genes for thyroid function, we conducted the first large-scale transcriptome-wide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 34962261
DOI: 10.1093/hmg/ddab371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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