Article

Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathways and associations with thyroid disease susceptibility and age-of-onset

2022-12-22

Abstract excerpt

Thyroid hormones play a critical role in regulation of multiple physiological functions and thyroid dysfunction is associated with substantial morbidity. Electronic health records were used to undertake the largest genome-wide association study of thyroid-stimulating hormone (TSH) levels, with a total sample size of 247,107. We identified 158 novel signals, more than doubling the number of known associations with...

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Identifiers and source

Literature Corpus work: 108e1803-503f-54e5-8448-69760aeff101
DOI: 10.1101/2022.12.22.22283779

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