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Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathways and associations with thyroid disease

23 Oct 2023

Abstract excerpt

Thyroid hormones play a critical role in regulation of multiple physiological functions and thyroid dysfunction is associated with substantial morbidity. Here, we use electronic health records to undertake a genome-wide association study of thyroid-stimulating hormone (TSH) levels, with a total sample size of 247,107. We identify 158 novel genetic associations, more than doubling the number of known associations...

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PMID: 37872160
DOI: 10.1038/s41467-023-42284-5

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