Article
Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function.
Human molecular genetics - 15 Jul 2012
Rawal Rajesh, Teumer Alexander, Völzke Henry, Wallaschofski Henri, Ittermann Till, Åsvold Bjørn O, Bjøro Trine, Greiser Karin H, Tiller Daniel, Werdan Karl, Meyer zu Schwabedissen Henriette E, Doering Angela, Illig Thomas, Gieger Christian, Meisinger Christa, Homuth Georg
Abstract excerpt
Thyroid hormones play key roles in cellular growth, development and metabolism. Although there is a strong genetic influence on thyroid hormone levels, the genes involved are widely unknown. The levels of circulating thyroid hormones are tightly regulated by thyrotropin (TSH), which also represents the most important diagnostic marker for thyroid function. Therefore, in order to identify genetic loci associated...
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