Article

Public Cohort Analysis Identifies Thyroglobulin Variants as Hypothyroidism Risk Factors

2025-11-24

Abstract excerpt

Hypothyroidism is a prevalent endocrine disorder characterized by insufficient thyroid hormone (T3T4) production. Thyroglobulin (Tg) serves as the prohormone for T3 and T4 production, with many variants of uncertain clinical significance due to genetic diversity in the Tg gene. We leveraged the large-scale All of Us biobank to investigate the disease association of prevalent yet undercharacterized Tg variants. We...

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Literature Corpus work: 12697ef5-fb03-5181-bea0-2d3eb10b4732
DOI: 10.1101/2025.11.21.689591

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