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Article

Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications

30 Jan 2024

Abstract excerpt

To date only a fraction of the genetic footprint of thyroid function has been clarified. We report a genome-wide association study meta-analysis of thyroid function in up to 271,040 individuals of European ancestry, including reference range thyrotropin (TSH), free thyroxine (FT4), free and total triiodothyronine (T3), proxies for metabolism (T3/FT4 ratio) as well as dichotomized high and low TSH levels. We...

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PMID: 38291025
DOI: 10.1038/s41467-024-44701-9

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