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Article

Testing for a causal role of thyroid hormone measurements within the normal range on human metabolism and diseases: a systematic Mendelian randomization.

EBioMedicine - 1 Sept 2024

Alwan Heba, Luan Jian'an, Williamson Alice, Carrasco-Zanini Julia, Stewart Isobel D, Wareham Nicholas J, Langenberg Claudia, Pietzner Maik

Abstract excerpt

BACKGROUND: Variation in thyroid function parameters within the normal range has been observationally associated with adverse health outcomes. Whether those associations reflect causal effects is largely unknown. METHODS: We systematically tested associations between genetic differences in thyrotropin (TSH) and free thyroxine (FT4) within the normal range and more than 1100 diseases and more than 6000 molecular...

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Identifiers

PMID: 39191175
DOI: 10.1016/j.ebiom.2024.105306
PMCID: PMC11400601

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