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Article

A chimeric mouse model to study human iPSC-derived neurons: the case of a truncating SHANK3 mutation.

Scientific reports - 7 Aug 2020

Vitrac Aline, Pons Stéphanie, Balkota Marta, Lemière Nathalie, Raïs Célia, Bourgeois Jean-Pierre, Maskos Uwe, Bourgeron Thomas, Cloëz-Tayarani Isabelle

Abstract excerpt

Using human induced pluripotent stem cells (iPSC), recent studies have shown that the events underlying autism spectrum disorders (ASD) can occur during neonatal development. We previously analyzed the iPSC-derived pyramidal cortical neurons of a subset of patients with ASD carrying de novo heterozygous mutations in postsynaptic SHANK3 protein, in culture. We reported altered spinogenesis of those neurons. The...

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Identifiers

PMID: 32769989
DOI: 10.1038/s41598-020-70056-4
PMCID: PMC7414912

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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