Article

Extracellular Vesicles from Stem cells Rescue Cellular Phenotypes and Behavioral Deficits in SHANK3-Associated ASD Neuronal and Mouse Models

2024-08-27

Abstract excerpt

<h4>ABSTRACT</h4> Extracellular vesicles (EVs) are lipid membrane-bound structures that mediate intercellular communication by transferring diverse cargoes, including RNA and proteins. Shank3 , a synaptic scaffolding protein critical for synapse structure and function, is implicated in autism spectrum disorder (ASD) and Phelan-McDermid Syndrome (PMS). Early hyperexcitability in cortical neurons is a recognized e...

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Literature Corpus work: b198ac94-fea9-540e-8061-58d7acc5e156
DOI: 10.1101/2024.08.27.609917

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