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Article

ProNGF inhibits NGF-mediated TrkA activation in PC12 cells.

Journal of neurochemistry - 1 Dec 2008

Sobottka Bettina, Reinhardt Dieter, Brockhaus Manfred, Jacobsen Helmut, Metzger Friedrich

Abstract excerpt

Degeneration of cholinergic basal forebrain neurons (CBFN) is a hallmark in the pathology of Alzheimer's disease (AD). Critically depending upon the neurotrophic support through nerve growth factor (NGF), CBFN in the AD brain face elevated concentrations of the pro-form of NGF (proNGF) and suffer from an imbalance between TrkA and p75(NTR) expression. Research for the underlying mechanisms of CBFN death suggested...

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Source

Identifiers

PMID: 18796003
DOI: 10.1111/j.1471-4159.2008.05690.x

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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