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Article

Proteolytic processing of proNGF is necessary for mature NGF regulated secretion from neurons.

Biochemical and biophysical research communications - 28 Sept 2007

Lim Kuei-Cheng, Tyler Carolyn M, Lim Seung T, Giuliano Rita, Federoff Howard J

Abstract excerpt

Nerve growth factor mediates neuronal survival, synaptogenesis, and synaptic remodeling. We utilized primary hippocampal cultures to investigate the intrinsic motifs of proNGF that might contribute to its processing and subsequent allocation to a regulated versus constitutive secretory pathway. The addition of a carboxypeptidase E motif to proNGF did not alter the secretion of NGF. However, mutagenesis of proNGF...

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Source

Identifiers

PMID: 17673176
DOI: 10.1016/j.bbrc.2007.07.039

Genes

NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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