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Article

Human ProNGF: biological effects and binding profiles at TrkA, P75NTR and sortilin.

Journal of neurochemistry - 1 Nov 2008

Clewes Oliver, Fahey Mark S, Tyler Sue J, Watson Judy J, Seok Heon, Catania Caterina, Cho Kwangwook, Dawbarn David, Allen Shelley J

Abstract excerpt

Nerve growth factor (NGF) promotes cell survival via binding to the tyrosine kinase receptor A (TrkA). Its precursor, proNGF, binds to p75(NTR) and sortilin receptors to initiate apoptosis. Current disagreement exists over whether proNGF acts neurotrophically following binding to TrkA. As in Alzh...

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Source

Identifiers

PMID: 18808449
DOI: 10.1111/j.1471-4159.2008.05698.x

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18808449-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Human ProNGF: biological effects and binding profiles at TrkA, P75NTR and sortilin.PMID 18808449Read ↗

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