Article
Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases.
Proceedings of the National Academy of Sciences of the United States of America - 12 Apr 2022
Dai Yu-Ting, Zhang Fan, Fang Hai, Li Jian-Feng, Lu Gang, Jiang Lu, Chen Bing, Mao Dong-Dong, Liu Yuan-Fang, Wang Jin, Peng Li-Jun, Feng Chong, Chen Hai-Feng, Mu Jun-Xi, Zhang Qun-Ling, Wang Hao, Ariffin Hany, Moy Tan Ah, Wang Jing-Han, Lou Yin-Jun, Chen Su-Ning, Wang Qian, Liu Hong, Shan Zhe, Matsumura Itaru, Miyazaki Yasushi, Yasuda Takahiko, Dou Li-Ping, Yan Xiao-Jing, Yan Jin-Song, Yeoh Allen Eng-Juh, Wu De-Pei, Kiyoi Hitoshi, Hayakawa Fumihiko, Jin Jie, Wang Sheng-Yue, Sun Xiao-Jian, Mi Jian-Qing, Chen Zhu, Huang Jin-Yan, Chen Sai-Juan
Abstract excerpt
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy of T cell progenitors, known to be a heterogeneous disease in pediatric and adult patients. Here we attempted to better understand the disease at the molecular level based on the transcriptomic landscape of 707 T-ALL patients (510 pediatric, 190 adult patients, and 7 with unknown age; 599 from published cohorts and 108 newly...
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