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Epigenetic Modifications in Pediatric Acute Lymphoblastic Leukemia

14 May 2014

Abstract excerpt

Aberrant epigenetic modifications are well-recognized drivers for oncogenesis. Pediatric acute lymphoblastic leukemia (ALL) is no exception and serves as a model toward the significant impact these heritable alterations can have in leukemogenesis. In this brief review, we will focus on the main aspects of epigenetics, which control leukemogenesis in pediatric ALL, mainly DNA methylation, histone modification, and...

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PMID: 24860797
DOI: 10.3389/fped.2014.00042

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