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Article

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen

14 Aug 2017

Abstract excerpt

Middle East respiratory syndrome coronavirus (MERS-CoV) is a lineage C betacoronavirus that since its emergence in 2012 has caused outbreaks in human populations with case-fatality rates of ∼36%. As in other coronaviruses, the spike (S) glycoprotein of MERS-CoV mediates receptor recognition and membrane fusion and is the primary target of the humoral immune response during infection. Here we use structure-based...

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PMID: 28807998
DOI: 10.1073/pnas.1707304114

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