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Multi-modal molecular programs regulate melanoma cell state

9 Jul 2022

Abstract excerpt

Melanoma cells display distinct intrinsic phenotypic states. Here, we seek to characterize the molecular regulation of these states using multi-omic analyses of whole exome, transcriptome, microRNA, long non-coding RNA and DNA methylation data together with reverse-phase protein array data on a panel of 68 highly annotated early passage melanoma cell lines. We demonstrate that clearly defined cancer cell...

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PMID: 35810190
DOI: 10.1038/s41467-022-31510-1

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